I used InDesign a bit in University, but used Quark since starting my current job over 1 year ago. Personally I don't think there is too much drastic difference between the two.
I assume InDesign has better integration with the other Adobe products, but Quark works just fine for our needs.
Unfortunately our version of Quark at work is ancient so I couldn't really say if one was better than the other - I think it comes down to personal preference tbh.


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