Coda - Great dreamweaver alternative. Coda has a built in ftp so you can upload as you work. A few things it has that i really like are the terminal window for working with your database and such, built in reference books for html, css, and php, code help like in dreamweaver.
Panic - Coda - One-Window Web Development for Mac OS X
Painter X - Recently i have been doing alot more illustrating, and I found painter x to have much better brush algorithms than photoshop or illustrator. More control over your line work, and coloring is much better. One of the biggest reasons i switched to painter was the ability to freely rotate the entire canvas on the fly. Now i can draw with a much more natural wrist movement feel, like working on paper.
Painter X - Digital Painting